ABSTRACT
As the biggest macrophage cells population in human body and the most important immune cells in the liver,Kupffer cells play a very important role in infection,inflammation,lipid metabolism and liver transplantation,and regulates various physiological and pathological processes.However,little is known about the role and mechanism in the tumorigenesis and tumor progression of Kupffer cells which as a kind of such important immune cells.In this paper,we summarized published researches and our experimental results about Kupffer cells,and reviewed the relationship between Kupffer cells and hepatocellular carcinoma from aspects of phagocytosis,secretary and antigen presentation.We hold that,at the early age of liver diseases,Kupffer cells inhibit tumorigenesis of hepatocellular carcinoma by its functions of phagocytosis,secretary and antigen presentation;however,when inflammation persists,Kupffer cells could induce tumorigenesis of hepatocellular carcinoma by secretary mechanism.
ABSTRACT
Objective To systematically evaluate the comparison of postoperative complications of laparoscopic splenectomy (LS) versus open splenectomy (OS) for hypersplenism secondary to portal hypertension of liver cirrhosis .Methods Clinical trials ,which compared the postoperative complications of LS versus OS for portal hypertension of liver cirrhosis from the PubMed ,Cochrane Li‐brary ,EMbase ,CNKI and CBM data bases from 2000 to 2013 and the RevMan 5 .2 software was used for data analysis .Results six trials with 456 patients were included .Meta‐analysis showed that there was no significant difference in incidences of postoperative bleeding(OR=0 .52 ,95% CI 0 .25 -1 .06 ,P=0 .07)or pancreatic fistual(OR=1 .09 ,95% CI 0 .33 -3 .60 ,P=0 .89) between LS and OS groups .Incidence of postoperative infection was decreased in LS group compared with OS group (OR=0 .17 ,95% CI 0 .07-0 .38 ,P<0 .01) .However ,the incidence of postoperative portal venous thrombosis was increased in LS group compared with OS group(OR=2 .14 ,95% CI 1 .23 -3 .73 ,P=0 .00) .Conclusion LS and OS own the same incidence of postoperative bleeding and pancreatic fistual .The incidence of postoperative infection was decreased in LS group compared with OS group ,meanwhile ,LS group was increased compared with OS group on incidence of postoperative portal venous thrombosis .